CLINICAL TRIALS AND OBSERVATIONS Characterization and treatment of chronic active Epstein-Barr virus disease: a 28-year experience in the United States
نویسندگان
چکیده
Jeffrey I. Cohen,1 Elaine S. Jaffe,2 Janet K. Dale,1 Stefania Pittaluga,2 Helen E. Heslop,3 Cliona M. Rooney,3 Stephen Gottschalk,3 Catherine M. Bollard,3 V. Koneti Rao,1 Adriana Marques,1 Peter D. Burbelo,4 Siu-Ping Turk,1 Rachael Fulton,1 Alan S. Wayne,5 Richard F. Little,6 Mitchell S. Cairo,7 Nader K. El-Mallawany,7 Daniel Fowler,8 Claude Sportes,8 Michael R. Bishop,8 Wyndham Wilson,9 and *Stephen E. Straus1
منابع مشابه
CLINICAL OBSERVATIONS, INTERVENTIONS, AND THERAPEUTIC TRIALS Clinical and virologic characteristics of chronic active Epstein-Barr virus infection
Thirty patients with chronic active Epstein-Barr virus (CAEBV) infection were analyzed. The study group included 18 male and 12 female patients, ranging in age from 5 to 31 years with a mean age of 14.2 years. Not all patients had high titers of EBV-specific antibodies, but all patients had high viral loads in their peripheral blood (more than 102.5 copies/mg DNA). Fifty percent of the patients...
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We have investigated the in vivo safety, efficacy, and persistence of autologous Epstein Barr virus (EBV)–specific cytotoxic T lymphocytes (CTLs) for the treatment of solid organ transplant (SOT) recipients at high risk for EBV-associated posttransplantation lymphoproliferative disease (PTLD). EBV-CTLs generated from 35 patients expanded with normal kinetics contained both CD8 and CD4 lymphocyt...
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BACKGROUND Nervous system complications of primary Epstein-Barr virus (EBV) infection in adults are rare, but may occur with encephalitis, meningitis, myelitis, cranial and peripheral neuropathies, or radiculitis. CASE PRESENTATION We describe an immune competent adult with a primary EBV infection complicated by lumbosacral polyradiculitis with pure radicular pain. Prior to the onset of radic...
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A semiquantitative polymerase chain reaction assay was used to monitor the blood levels of Epstein-Barr virus (EBV)DNA in 9 patients receiving allogeneic bone marrow transplants (BMT). Four of 5 recipients of HLA-mismatched T-cell– depleted grafts showed a 4to 5-log increase of EBV-DNA within 1 to 3 months after BMT. Administration of 2 to 4 infusions of 107 EBV-specific cytotoxic Tlymphocytes ...
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Severe T-cell immunodeficiency after solid organ or bone marrow transplantation may result in the uncontrolled outgrowth of latently Epstein-Barr virus–infected B cells, leading to B-lymphoproliferative disorder (BLPD). Given the potentially important pathogenic role of IL-6 in BLPD, it was tested whether the in vivo neutralization of IL-6 by a monoclonal anti–IL-6 antibody could contribute to ...
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